The present study aimed to investigate the hypoglycemic effect of fish oil and both docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on body and organs weight, lipid profile, enzyme activities and the histology of pancreatic β-islets of langherhans and liver hepatocyte of male alloxan-induced diabetic rats. Sixty rats were divided into six equal groups’ ten rats each: control, fish oil, DHA+EPA, diabetic (D), D + fish oil and D+ (DHA+EPA). Treatment of diabetic rats with fish oil and both DHA and EPA showed improvement in body and organs weights compared to diabetic group. Also, the treatments caused significant decrease in plasma glucose level, urea, creatinine and bilirubin and increase in plasma total protien, albumin and globulin compared to diabetic group. Treatments restored the enzymes activities in plasma and organs near their normal levels. The noticeable improvement in the histological alterations of pancreas and liver of alloxan -diabetic rats treated with fish oil and both DHA and EPA were supported by the biochemical findings. Treating rats with fish oil and both DHA and EPA is promising. However, it is advisable to use each of them as hypoglycemic agents.
|Keywords:||Fish Oil, Diabetes, Rats|
Lecturer of Food Analysis, Nutrition Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt